国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (5): 445-451.doi: 10.3760/ cma.j.issn.1673-5803.2023.05.010

• 综述 • 上一篇    下一篇

眼睑恶性黑色素瘤的研究进展

李玉文1 马建民2   

  1. 1潍坊医学院,山东潍坊 261042;2首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室,北京 100730
  • 收稿日期:2023-01-13 出版日期:2023-10-22 发布日期:2023-11-06
  • 通讯作者: 马建民,Email:jmma@sina.com E-mail:jmma@sina.com
  • 基金资助:
    北京市自然科学基金(7222025);北京市医院管理中心“登峰”人才培养计划(DFI 20190201)

Research progress of eyelid malignant melanoma

Li Yuwen1, Ma Jianmin2   

  1. 1Weifang Medical College, Weifang Shandong 261042, China;2 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Vision Science, Beijing 100730, China
  • Received:2023-01-13 Online:2023-10-22 Published:2023-11-06
  • Contact: Ma Jianmin, Email: jmma@sina.com E-mail:jmma@sina.com
  • Supported by:
    Beijing Natural Sciences Fundation(7222025); Special Fund for "Peak Climbing" Plan of Beijing Hospital Management Center (DFJ20190201)

摘要: 眼睑黑色素瘤(malignant melanoma of eyelid,MME)是一种较为少见的眼肿瘤,其恶性度高,进展迅速,预后差,占眼睑肿瘤不到1%,近年呈增加趋势。MME起源于痣细胞、表皮或真皮的黑色素细胞。老年人为发病主要人群,该病多发于内、外眦,并向皮肤、结膜两个方向发展,其发展过程具有很大的变异度,可能迅速长成大肿块,可能缓慢增大,也可能局部病灶虽小,但早已发生远处转移。可做免疫组化检测进行诊断,晚期患者平均存活时间为7.5个月,2年和5年生存率分别为15%和5%,早诊断早行手术切除是治疗黑色素瘤的最佳选择。

关键词: 眼睑, 黑色素瘤

Abstract: Malignant melanoma of eyelid(MME) is a rare ocular tumor characterized by high malignancy, rapid progression and poor prognosis, accounting for less than 1% of eyelid tumors. MME has an increasing tendency in recent years. MME originates from nevus cells, epidermal melanocytes, or dermal melanocytes. The elderly population is the main group at risk for developing MME, which mainly occurs in the inner and outer canthus and develops in the direction of skin and conjunctiva. The development process is highly variable, which may rapidly grow into a large mass, or slowly increase. Sometimes the local lesions may be small, but distant metastasis has already occurred. The average survival time of late-stage patients is 7.5 months, and the 2-year and 5-year survival rates are 15% and 5% respectively. Early diagnosis and early surgical resection is the best choice to cure MME.

Key words: eyelid, melanoma